Membrane Protein Analysis (GPCRs)

Kinetic Discovery’s speciality is providing services in membrane protein research. Proteins such as GPCRs are difficult targets as they are embedded in membranes which complicate their study. Kinetic Discovery has unique experience with application of SPR biosensors for studying membrane proteins. SPR can be used to screen solubilisation/stabilisation conditions for membrane proteins or determination of binding kinetics of ligands to solubilised GPCRs. Obtained information can be used either to optimise crystallisation conditions for GPCRs or to improve compound properties.